Have you heard about the scrapbook method called Rule of thirds? I did and thought ...oh no MATH??! Nope Nope that is why we use Simples!
Basically Rule of Thirds means, if you had a grid like this on your layout, you would want the main focal points to fall on the 4 way intersections. For me, the focal points on any layout is photos so Simples place the photo spaces on those intersections.